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N-Hydroxyphthalimide → 1-Acetyl-3,5-dimethyl Adamantane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Hydroxyphthalimide | HCID 10665 | — |
| 反応物 | 1-Acetyl-3,5-dimethyl-7-adamantanol | HCID 13464074 | — |
| 生成物 | 3,5-Dimethyl-1-adamantanol | HCID 265793 | 7% |
| 生成物 | 1-Acetyl-3,5-dimethyl Adamantane | HCID 12113124 | 32% |
| 生成物 | 1,3-Diacetyl-5,7-dimethyladamantane | HCID 12113141 | 2% |
| 生成物 | 1,3-Dimethyl-4-adamantanone | HCID 12644332 | 5% |
反応手順
Except that the amount of N-hydroxyphthalimide was changed to 0.6 mmol, the procedure of Example 9 was repeated to give 1-acetyl-3,5-dimethyladamantane (yield 32%, selectivity 54%), 1,3-diacetyl-5,7-dimethyladamantane (yield 2%, selectivity 3%), 1-acetyl-3,5-dimethyl-7-adamantanol (yield %, selectivity 2%), 1,3-dimethyl-5-adamantanol (yield 7%, selectivity 12%), and 1,3-dimethyl-4-adamantanone (yield 5%, selectivity 8%), at a conversion rate from 1,3-dimethyladamantane of 59%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06429314B1 |
| 出典データセット | uspto-grants-2002_08 |
| ORD ID | ord-7d1ff4c668d94946a51b76cdc3322555 |
| 出典メモ | uspto-grants-2002_08 |