3,4-Dichloroaniline → Ethyl N-(3,4-dichlorophenyl)alaninate

HRID 23022

反応式

HRID 23022 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[C:10]([O:15][CH2:16][CH3:17])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1)[CH3:17]

参加物

3

反応物 2

HCID 72573,4-DichloroanilineHCID 12041Ethyl pyruvate

生成物 1

HCID 169545Ethyl N-(3,4-dichlorophenyl)alaninate

実験手順

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

後処理

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification

出典と根拠

ORDレコード
ord-28579255812e46f98e9e94264cb44c6d
出典データセット
uspto-grants-2005_02
特許番号
US06849650B2

関連ノート

読み込み中…