Pyridine-2-carbonitrile → 6-Methylthieno[2,3-d]pyrimidine

反応式

[C:1](C1C=CC=CN=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([CH3:20])=[CH:13][C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)Cl>>[CH3:20][C:12]1[S:11][C:10]2[N:9]=[CH:1][N:2]=[CH:15][C:14]=2[CH:13]=1

参加物

反応物 3

HCID 7522Pyridine-2-carbonitrile

HCID 24813Phosphorus oxychloride

HCID 4062885Ethyl 2-Amino-5-methylthiophene-3-carboxylate

生成物 1

HCID 217930776-Methylthieno[2,3-d]pyrimidine

実験手順

With the procedure of Example 477, the reaction of 2-cyanopyridine and 2-amino-5-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-pyridin-2-yl)-6-methyl-thieno-[2,3-d]-pyrimidine.

出典と根拠

ORDレコード: ord-626b4d47b2054053855e76b00ae2e623
出典データセット: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06432950B1

反応ノート

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