3,4-Dichloroaniline → N-(3,4-dichlorophenyl)alanine n-butyl Ester
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[C:10]([O:15][CH2:16][CH2:17][CH2:18][CH3:19])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1)[CH2:17][CH2:18][CH3:19]参加物
3
実験手順
Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and n-butyl pyruvate (prepared by following General Procedure AO above using n-butanol in place of iso-butanol), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.7 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).
後処理
- customThe reaction was monitored by tlc on silica gel (Rf=0.7 in 25% EtOAc/hexanes) and purification
出典と根拠
- ORDレコード
- ord-87a7dbd989cf49bd97be568882e3fa79
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849650B2
反応ノート
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