Bromine → 6-Bromothieno[2,3-d]pyrimidin-4(1H)-one
反応式
[N:1]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[C:4](=[O:10])[NH:3][CH:2]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[S:7][C:6]2[N:1]=[CH:2][NH:3][C:4](=[O:10])[C:5]=2[CH:9]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
The product from Example 14 (0.75 g) was added to glacial acetic acid (10 ml) and heated with stirring until it dissolved. Bromine (0.75 ml) was then added and the mixture immediately set solid. More acetic acid was added and the mixture broken up. It was then heated at 80° C. for 6½ hours, cooled and poured into ice-water. The solid was filtered and washed with water followed by dichloromethane and dried to give the title product, m.p. 304° C.
後処理
- temperatureheated
- dissolutiondissolved
- temperaturecooled
- filtrationThe solid was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-cfb501c821434c1eb4f22d04d0d9863f
- 出典データセット
- uspto-grants-2002_08
- 特許番号
- US06432964B1
反応ノート
読み込み中…