HCID 18461418、化合物 → 5-{4-[6-(3,5-Di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

HRID 2303802ノート

反応式

HRID 2303802 の反応式
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:50]=[CH:49][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[C:29]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:28]([OH:35])=[C:27]([C:36]([CH3:39])([CH3:38])[CH3:37])[CH:26]=4)=[CH:20][C:19]=3[N:40]([CH3:48])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:51].O1CCOCC1>>[ClH:51].[C:36]([C:27]1[CH:26]=[C:25]([CH:30]=[C:29]([C:31]([CH3:32])([CH3:34])[CH3:33])[C:28]=1[OH:35])[O:24][C:21]1[CH:22]=[CH:23][C:18]2[N:17]=[C:15]([CH2:14][O:13][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH:4]4[S:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])=[CH:50][CH:49]=3)[N:40]([CH3:48])[C:19]=2[CH:20]=1)([CH3:39])([CH3:38])[CH3:37]

参加物

3

反応物 2

HCID 18461418HCID 18461418、化合物HCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 867584465-{4-[6-(3,5-Di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

実験手順

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3,5-di-t-butyl-4-hydroxyphenoxy)phenyl}-N-methylcarbamate (0.72 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at room temperature for 17 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (0.41 g).

後処理

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-175f68421dd7418787cc934b4fdeeeda
出典データセット
uspto-grants-2002_08
特許番号
US06432993B1

反応ノート

読み込み中…