化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloro-4-fluorobenzonitrile → n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-4-fluorobenzonitrile | HCID 109000 | — |
| 反応物 | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| 生成物 | n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester | HCID 53791223 | — |
反応手順
Following General Procedure AP above and using 2-chloro-4-fluorobenzonitrile (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example AA above), the title compound was prepared. The product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849650B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-a4bbed5dd2044f3fadb7ea98748fef7c |
| 出典メモ | uspto-grants-2005_02 |