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Dimethylformamide → 8-Hydroxyjulolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | 3-Aminophenol | HCID 11568 | — |
| 生成物 | 8-Hydroxyjulolidine | HCID 170474 | 62% |
反応手順
According to a procedure similar to that of Embodiment 1, a mixture of m-aminophenol (5.0 g, 46 mmol), 1 -bromo-3-chloropropane (23.9 g, 15 ml, 151 mmol) and N,N-dimethylformamide (15 ml) was heated and refluxed for 15 hours. After silica gel column chromatography, 8-hydroxyjulolidine (5.5 g) was obtained in 62% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06433176B1 |
| 出典データセット | uspto-grants-2002_08 |
| ORD ID | ord-80264873ef544886a3d4602d8773d5de |
| 出典メモ | uspto-grants-2002_08 |