Dimethylformamide → 8-Hydroxyjulolidine

HRID 2303939

反応式

HRID 2303939 の反応式
N[C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][CH2:12]Cl.[CH3:14][N:15]([CH3:18])[CH:16]=O>>[CH2:10]1[CH2:18][N:15]2[C:14]3[C:5]([CH2:6][CH2:7][CH2:16]2)=[C:4]([OH:8])[CH:3]=[CH:2][C:12]=3[CH2:11]1

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 80061-Bromo-3-chloropropaneHCID 115683-Aminophenol

生成物 1

HCID 1704748-Hydroxyjulolidine収率 62%

実験手順

According to a procedure similar to that of Embodiment 1, a mixture of m-aminophenol (5.0 g, 46 mmol), 1 -bromo-3-chloropropane (23.9 g, 15 ml, 151 mmol) and N,N-dimethylformamide (15 ml) was heated and refluxed for 15 hours. After silica gel column chromatography, 8-hydroxyjulolidine (5.5 g) was obtained in 62% yield.

後処理

  1. temperaturewas heated
  2. temperaturerefluxed for 15 hours

出典と根拠

ORDレコード
ord-80264873ef544886a3d4602d8773d5de
出典データセット
uspto-grants-2002_08
特許番号
US06433176B1

関連ノート

読み込み中…