Ethanol → 8-Hydroxyjulolidine

HRID 2303941

反応式

HRID 2303941 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][CH2:12]Cl.[C:14]([O-])(O)=O.[Na+].[CH2:19](O)[CH3:20]>>[CH2:11]1[CH2:12][N:1]2[C:2]3[C:3]([CH2:14][CH2:19][CH2:20]2)=[C:4]([OH:8])[CH:5]=[CH:6][C:7]=3[CH2:10]1

参加物

5

反応物 4

HCID 702EthanolHCID 80061-Bromo-3-chloropropaneHCID 115683-AminophenolHCID 516892Sodium Bicarbonate

生成物 1

HCID 1704748-Hydroxyjulolidine収率 39%

実験手順

According to a procedure similar to that of Embodiment 5, a mixture of m-aminophenol (5.0 g, 45.8 mmol), 1-bromo-3-chloropropane (23.9 g, 15 ml, 150 mmol) and ethanol (50 ml) was heated and refluxed. NaHCO3 (10.0 g, 119 mmol) aqueous solution (20 ml) was added slowly. After 24 hours of reflux, 3.4 g of 8-hydroxyjulolidine was obtained in 39% yield.

後処理

  1. temperaturewas heated
  2. temperaturerefluxed
  3. temperatureAfter 24 hours of reflux

出典と根拠

ORDレコード
ord-a5fd6cbee54040239240a353d2500eff
出典データセット
uspto-grants-2002_08
特許番号
US06433176B1

関連ノート

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