4,6-Dichloro-5-(4-methylphenyl)pyrimidine → 4-Amino-6-chloro-5-(4-methylphenyl)pyrimidine

HRID 2304

反応式

HRID 2304 の反応式
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH3:16].C(O)C>CCOCC>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([NH2:16])[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 219795544,6-Dichloro-5-(4-methylphenyl)pyrimidineHCID 22020343Ethanol, reaction products with ammonia, distn. residues

生成物 1

HCID 189311004-Amino-6-chloro-5-(4-methylphenyl)pyrimidine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 4,6-dichloro-5-(4-methylphenyl)pyrimidine (4.14 g) in ether (20 ml) is added 27% ammonia-ethanol solution (30 ml), and the reaction mixture is reacted at room temperature in a sealed tube for three days. The mixture is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=(10:1)~ethyl acetate) to give 6-chloro-5-(4-methylphenyl)pyrimidin-4-amine (1.89 g).

後処理

  1. customthe reaction mixture is reacted at room temperature in a sealed tube for three days
  2. concentrationThe mixture is concentrated under reduced pressure
  3. customthe residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=(10:1)~ethyl acetate)

出典と根拠

ORDレコード
ord-bd67cbfc2bdf4149825d464041c6164c
出典データセット
uspto-grants-1998_03
特許番号
US05728706

関連ノート

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