5-Bromoisoquinoline → 7-Bromoisoquinoline N-oxide hydrochloride

反応式

[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.BrC1C=CC=C2C=1C=CN=C2.[ClH:23].BrC1C=CC=C2C=1C=C[N+]([O-:35])=C2>>[ClH:23].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N+:8]([O-:35])=[CH:9]2)=[CH:4][CH:3]=1

参加物

反応物 3

HCID 7364875-Bromoisoquinoline

HCID 122574417-Bromoisoquinoline2 回

HCID 226657075-bromoisoquinoline N-oxide hydrochloride

生成物 1

HCID 226659267-Bromoisoquinoline N-oxide hydrochloride

実験手順

Compound 37a was prepared from 7-bromoisoquinoline (Tyson, F. L., J. Am. Chem. Soc. 61, 183 (1939), this procedure gave a mixture of 7-bromoisoquinoline and 5-bromoisoquinoline) using the procedure described for 1a. The title compound was contaminated with the 5-bromoisoquinoline N-oxide hydrochloride. M.p. 107.0-112.5° C.

後処理

custom61, 183 (1939), this procedure gave

出典と根拠

ORDレコード: ord-9e375c71fe184e6e8c332d2aed41e69c
出典データセット: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06432955B1

反応ノート

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