Phosphorus oxychloride → 1-Chloro-7-methoxyisoquinoline

HRID 2304296ノート

反応式

HRID 2304296 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][N+:10]([O-])=[CH:11]2)=[CH:6][CH:5]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:11]1[C:12]2[C:7](=[CH:6][CH:5]=[C:4]([O:3][CH3:2])[CH:13]=2)[CH:8]=[CH:9][N:10]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 226656837-Methoxy-isoquinoline-N-oxide hydrochloride

生成物 1

HCID 222501811-Chloro-7-methoxyisoquinoline

反応条件

温度
90 °C

実験手順

7-Methoxy-isoquinoline-N-oxide hydrochloride (38.2 g) was added in portions to phosphoryl chloride (275 mL) and the mixture heated at 90° C. for 6 h. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacuo.

後処理

  1. customExcess of phosphoryl chloride was removed in vacuo
  2. washThe remaining white solid was washed with water
  3. filtrationfiltered
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-3efc43c5009b47909fc38669bd0e214b
出典データセット
uspto-grants-2002_08
特許番号
US06432955B1

反応ノート

読み込み中…