Water → N-[5-Phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]acetamide

HRID 2304606ノート

反応式

HRID 2304606 の反応式
[C:1]1([C:7]2[S:11][C:10]([NH2:12])=[N:9][C:8]=2[C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19](Cl)(=[O:21])[CH3:20].O>CN(C)C(=O)C>[C:1]1([C:7]2[S:11][C:10]([NH:12][C:19](=[O:21])[CH3:20])=[N:9][C:8]=2[C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 9794996[5-Phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]amine

生成物 1

HCID 22993726N-[5-Phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]acetamide収率 59%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

反応条件

温度
80 °C

実験手順

To a solution of [5-phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]amine (1.10 g, 4.34 mmol) in N,N-dimethylacetamide (20 mL) was added acetyl chloride (680 mg, 8.68 mmol) and stirred at 80° C. for 3 h. Water was added to the reaction mixture and extracted with ethyl acetate twice. The combined organic phases were washed with water, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized from chloroform-ethyl ether to give the title compound (750 mg, yield 59%).

後処理

  1. extractionextracted with ethyl acetate twice
  2. washThe combined organic phases were washed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from chloroform-ethyl ether

出典と根拠

ORDレコード
ord-efaf2f3515e045268fab138e9808aadf
出典データセット
uspto-grants-2002_08
特許番号
US06436966B1

反応ノート

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