Hydrochloric Acid → Methyl 4-(2-aminoethyl)benzoate hydrochloride
反応式
C(OC([NH:8][CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:21]>C(Cl)Cl.O1CCOCC1>[ClH:21].[NH2:8][CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=1参加物
5
実験手順
To a solution of methyl 4-[2-(tert-butoxycarbonylamino)ethyl]benzoate (3.50 g, 12.5 mmol) in methylene chloride (35 ml) was added 4N hydrogen chloride in 1,4-dioxane (35 ml) at 5° C. and the mixture was stirred for 30 min. The solvent was removed in vacuo and the resulting solid was collected, washed with isopropyl ether and dried to give methyl 4-(2-aminoethyl)-benzoate hydrochloride (2.63 g, 97%).
後処理
- customThe solvent was removed in vacuo
- customthe resulting solid was collected
- washwashed with isopropyl ether
- customdried
出典と根拠
- ORDレコード
- ord-d397bffb15f24cf88398ef427fe05ee3
- 出典データセット
- uspto-grants-2002_08
- 特許番号
- US06437146B1
反応ノート
読み込み中…