Hydrochloric Acid → HCID 70105295、化合物

反応式

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:41])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][CH:20]=[C:19]2[C:24]2[O:25][C:26]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:28]=2)[CH:12]=1.[ClH:42]>C(OCC)C.CCOC(C)=O>[ClH:42].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:41])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][CH:20]=[C:19]2[C:24]2[O:25][C:26]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:28]=2)[CH:12]=1

参加物

実験手順

To a solution of (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide (130 mg, 0.241 mmol) in ethyl ether (4 ml) was added 4N hydrogen chloride in EtOAc (0.5 ml) at room temperature. The solvent was removed in vacuo and the resulting solid was collected, washed with ethyl ether, and dried to give (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide hydrochloride (135.2 mg, 97%).