Hydrochloric Acid → N-(4-Pyridinylmethyl)urea
反応式
Cl.[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1.[O-:10][C:11]#[N:12].[Na+].[O-]C#N>O>[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:11]([NH2:12])=[O:10])=[CH:4][CH:3]=1参加物
6
実験手順
5.1 ml of 5N HCl was added to a solution of 2.53 ml of 4-picolylamine and 1.66 g of sodium cyanate in 50 ml of water. After 5 hours, a further 0.166 g of cyanate were added and the pH adjusted to 7.5. After 18 hours the reaction mixture was evaporated to dryness, the residue extracted with 100 ml of hot 2-propanol. The filtrate was concentrated, cooled and the solid collected to give the title compound (3.03 g) mp 194-6° C. A further 0.63 g could be isolated as second and third crops.
後処理
- customAfter 18 hours the reaction mixture was evaporated to dryness
- extractionthe residue extracted with 100 ml of hot 2-propanol
- concentrationThe filtrate was concentrated
- temperaturecooled
- customthe solid collected
出典と根拠
- ORDレコード
- ord-164fe147d2c4411fa9f9cae64beefb80
- 出典データセット
- uspto-grants-2002_08
- 特許番号
- US06440979B1
反応ノート
読み込み中…