Methyl pyruvate → N-(3,4-ethylenedioxyphenyl)alanine Iso-butyl Ester

HRID 23054

反応式

HRID 23054 の反応式
[C:1](OC)(=O)[C:2]([CH3:4])=O.[CH3:8][O:9][C:10](=[O:24])[C@H:11]([CH3:23])[NH:12][C:13]1[CH:18]=[CH:17][C:16]2[O:19][CH2:20][CH2:21][O:22][C:15]=2[CH:14]=1>C(O)C(C)C>[CH2:8]([O:9][C:10](=[O:24])[C@H:11]([CH3:23])[NH:12][C:13]1[CH:18]=[CH:17][C:16]2[O:19][CH2:20][CH2:21][O:22][C:15]=2[CH:14]=1)[CH:2]([CH3:4])[CH3:1]

参加物

4

反応物 2

HCID 11748Methyl pyruvateHCID 53867794N-(3,4-ethylenedioxyphenyl)alanine methyl ester

生成物 1

HCID 53856555N-(3,4-ethylenedioxyphenyl)alanine Iso-butyl Ester

試薬・触媒・溶媒 1

HCID 6560Isobutanol溶媒

実験手順

Following reductive amination General Procedure AA above and using 1,4-benzodioxa-6-amine (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-ethylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above using iso-butanol to provide the title compound. Purification was by preparative plate chromatography.

後処理

  1. customwas prepared

出典と根拠

ORDレコード
ord-7c12d267fe1f41bd994b7c07dd3a6b03
出典データセット
uspto-grants-2005_02
特許番号
US06849650B2

関連ノート

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