2-Naphthylamine → N-(2-naphthyl)alanine Methyl Ester
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[C:12]([O:17][CH3:18])(=[O:16])[C:13]([CH3:15])=O>>[CH3:18][O:17][C:12](=[O:16])[C@H:13]([CH3:15])[NH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1参加物
3
実験手順
Following reductive amination General Procedure AA above and using 2-aminonaphthalene (Aldrich) and methyl pyruvate (Aldrich), the title compound was prepared. The reaction was monitored by silica gel tlc (Rf=0.50 in 25% EtOAc/hexanes). Purification was by flash chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
後処理
- customPurification
出典と根拠
- ORDレコード
- ord-427cba692fe547f3a607f10f89acd3d0
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849650B2
反応ノート
読み込み中…