3-Amino-1,2-propanediol → (RS)-3-[2-(2,3-Dihydro-benzofuran-5-yl)-quinolin-4-ylamino]-propane-1,2-diol hydrochloride

反応式

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:13]=[CH:14][C:15]3[O:19][CH2:18][CH2:17][C:16]=3[CH:20]=2)[CH:3]=1.[NH2:21][CH2:22][CH:23]([OH:26])[CH2:24][OH:25]>>[ClH:1].[O:19]1[C:15]2[CH:14]=[CH:13][C:12]([C:4]3[CH:3]=[C:2]([NH:21][CH2:22][CH:23]([OH:26])[CH2:24][OH:25])[C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[N:5]=3)=[CH:20][C:16]=2[CH2:17][CH2:18]1

参加物

反応物 2

HCID 735613-Amino-1,2-propanediol

HCID 184330254-Chloro-2-(2,3-dihydro-benzofuran-5-yl)-quinoline

生成物 1

HCID 18432935(RS)-3-[2-(2,3-Dihydro-benzofuran-5-yl)-quinolin-4-ylamino]-propane-1,2-diol hydrochloride

実験手順

The title compound, m.p. 267-270° C. and MS: m/e=336 (M+), was prepared from 4-chloro-2-(2,3-dihydro-benzofuran-5-yl)-quinoline and (RS)-3-amino-1,2-propandiol.

出典と根拠

ORDレコード: ord-8f6ea7a5ec4541408e59708992e1f431
出典データセット: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06440995B1

反応ノート

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