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2-Naphthylamine → N-(2-naphthyl)alanine Ethyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Naphthylamine | HCID 7057 | — |
| 反応物 | Ethyl pyruvate | HCID 12041 | — |
| 生成物 | N-(2-naphthyl)alanine Ethyl Ester | HCID 11345542 | — |
反応手順
Following reductive amination General Procedure AA above and using 2-aminonaphthalene (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared as a solid having a melting point of 52-56° C. The reaction was monitored by silica gel tlc (Rf=0.50 in 25% EtOAc/hexanes). Purification was by flash chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849650B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-5197e12bfb334a10b3329c8112e9cee0 |
| 出典メモ | uspto-grants-2005_02 |