Triethylamine → (4-Methoxymethoxy-phenylethynyl)-trimethylsilane

HRID 2305607

反応式

HRID 2305607 の反応式
I[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][O:10][CH3:11])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:19][Si:20]([C:23]#[CH:24])([CH3:22])[CH3:21]>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu](I)I.O.C(OCC)(=O)C>[CH3:19][Si:20]([CH3:22])([CH3:21])[C:23]#[C:24][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][O:10][CH3:11])=[CH:4][CH:3]=1

参加物

7

反応物 3

HCID 8471TriethylamineHCID 66111TrimethylsilylacetyleneHCID 110327301-Iodo-4-(methoxymethoxy)benzene

生成物 1

HCID 10657368(4-Methoxymethoxy-phenylethynyl)-trimethylsilane

試薬・触媒・溶媒 3

HCID 83717Copper iodide触媒HCID 178418476HCID 178418476、化合物触媒HCID 22728543Water ethylacetate溶媒

実験手順

5.74 g (21.7 mmol) of 1-iodo-4-methoxymethoxybenzene, 100 ml of triethylamine and a mixture of 1.53 g (2.18 mmol) of dichlorobis(triphenylphosphine)palladium and 831 mg (4.37 mmol) of copper iodide are introduced into a three-necked flask. 6.14 ml (43.5 mmol) of trimethylsilylacetylene are then added and the medium is stirred for 48 h at room temperature. It is then poured into a water/ethyl acetate mixture. The organic phase is washed twice with water and, after separation of the phases by settling, it is washed with magnesium sulphate and concentrated.

後処理

  1. additionare introduced into a three-necked flask
  2. washThe organic phase is washed twice with water
  3. customafter separation of the phases
  4. washit is washed with magnesium sulphate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-107dc54a56b3407990ed501fdd2fb309
出典データセット
uspto-grants-2002_08
特許番号
US06441010B2

関連ノート

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