Ammonia → 7-nitro-1H-indole-2-carboxamide

HRID 230567ノート

反応式

HRID 230567 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13]([O:15]CC)=O)=[CH:9]2)([O-:3])=[O:2].[NH3:18]>>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13]([NH2:18])=[O:15])=[CH:9]2)([O-:3])=[O:2]

参加物

3

反応物 2

HCID 222AmmoniaHCID 250407Ethyl 7-nitro-1H-indole-2-carboxylate

生成物 1

HCID 473196987-nitro-1H-indole-2-carboxamide

反応条件

温度
50 °C

実験手順

A suspension of 133 mg (0.57 mmol) of ethyl 7-nitroindole-2-carboxylate in 3.84 ml of 28% aqueous ammonia is heated at 50° C. for 18 h in a stoppered glass tube. The reaction medium is filtered over sintered glass. The yellow solid obtained is washed with water and with cyclohexane and then dried under vacuum. 70 mg of 7-nitro-1H-indole-2-carboxamide are obtained in the form of a yellow solid.

後処理

  1. filtrationThe reaction medium is filtered over sintered glass
  2. customThe yellow solid obtained
  3. washis washed with water and with cyclohexane
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-aa1ca6611c304af49a226cf2de84133b
出典データセット
uspto-grants-2009_07
特許番号
US07566736B2

反応ノート

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