化工社化工社 化学情報印刷レポート · 研究参考用
L-Alanine → 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Alanine | HCID 5950 | — |
| 反応物 | Isobutanol | HCID 6560 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
反応手順
A mixture of 35.64 g (0.4 mol) of (D,L)-alanine (Aldrich) (or L-alanine (Aldrich)); 44 mL (0.6 mol) of thionyl chloride (Aldrich) and 200 mL of isobutanol was refluxed for 1.5 hours and the volatiles were removed completely on a rotavapor of 90° C. under reduced pressure to give (D,L)-alanine iso-butyl ester hydrochloride (or L-alanine iso-butyl ester hydrochloride), which was pure enough to be used for further transformations.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849650B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-67ada832f8c24662847c20f8da7631de |
| 出典メモ | uspto-grants-2005_02 |