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Trimethyl orthoformate → (1E)-1-methoxyimino-1-(2-methyl-1,3-dioxan-2-yl)propan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | 1,3-Propanediol | HCID 10442 | — |
| 反応物 | Diacetyl(methoxyimino)methane | HCID 536122 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 生成物 | (1E)-1-methoxyimino-1-(2-methyl-1,3-dioxan-2-yl)propan-2-one | HCID 22967233 | 94.6% |
反応手順
Starting from 103 g (0.72 mol) of pentane-2,3,4-trione 3-(O-methyloxime), 275 g (3.62 mol) of 1,3-propanediol, 80 g (0.76 mol) of trimethyl orthoformate and 1.6 g of p-toluenesulfonic acid (9 mmol) and using the procedure of Example 2, 137 g (94% yield) of a reddish oil were obtained which, according to HPLC, had a purity of 70% (phys. data see Tab. 1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06441236B1 |
| 出典データセット | uspto-grants-2002_08 |
| ORD ID | ord-1a4ddb7dcb0a428fa40c4d3c6cb35015 |
| 出典メモ | uspto-grants-2002_08 |