Sulfuryl chloride → 3-(Benzyloxy)benzene-1-sulfonyl chloride

HRID 2306181ノート

反応式

HRID 2306181 の反応式
[Br-].[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([S:16]([O-:18])=[O:17])[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Mg+2].S(Cl)([Cl:23])(=O)=O>C(Cl)Cl>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([S:16]([Cl:23])(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 22966386HCID 22966386、化合物

生成物 1

HCID 157296493-(Benzyloxy)benzene-1-sulfonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

Magnesium 3-benzyloxyphenylsulfinate bromide, as described above in Step B, (4.5 g, 14 mmol) was dissolved in dry CH2Cl2 (175 mL) and cooled to 0° C. under argon. Sulfuryl chloride (19 mL of a 1.0 M solution in CH2Cl2, 19 mmol) was added dropwise, and the mixture was stirred for 18 hours at ambient temperature, during which time a precipitate formed. The precipitate was removed by filtration and the filtrate was concentrated under reduced pressure to give the product as a yellow oil.

後処理

  1. customformed
  2. customThe precipitate was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-973767a9431f4601b10c27bf4cc83112
出典データセット
uspto-grants-2002_08
特許番号
US06441017B1

反応ノート

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