Benzenepropanoyl chloride → N-(3-phenylpropionyl)-D,L-alanine Isobutyl Ester

HRID 23065

反応式

HRID 23065 の反応式
[C:1]1([CH2:7][CH2:8][C:9](Cl)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH:20][C:9](=[O:10])[CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH:14]([CH3:16])[CH3:15]

参加物

3

反応物 2

HCID 64801Benzenepropanoyl chlorideHCID 862001092-Methylpropyl 2-aminopropanoate hydrochloride

生成物 1

HCID 15480461N-(3-phenylpropionyl)-D,L-alanine Isobutyl Ester

実験手順

Following General Procedure BA above and using 3-phenylpropionyl chloride (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of from 51°-54° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

後処理

  1. customof from 51°-54° C
  2. customThe reaction was monitored by tlc on silica gel and purification
  3. extractionwas by extraction with Et2O

出典と根拠

ORDレコード
ord-b4ada72309df474fa19249a38f0bf9b4
出典データセット
uspto-grants-2005_02
特許番号
US06849650B2

関連ノート

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