Hydrochloric Acid → 239113-23-6

HRID 2306856ノート

反応式

HRID 2306856 の反応式
[Cl:1][C:2]1[C:3]([CH:12]([N:20]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([NH2:20])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22629930HCID 22629930、化合物

生成物 1

HCID 69351932239113-23-6

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of the product from stage b) (1.29 g) in diethyl ether (5 ml) was added 1M hydrochloric acid (10 ml) at room temperature and the solution was stirred at room temperature for 2 hours. The mixture was filtered to give a solid, which was washed with water (15 ml) then ether (15 ml). Drying in vacuo gave the title product. Water was removed from the aqueous phase by azeotropic distillation with toluene (×3), to give further quantities of the title product.

後処理

  1. filtrationThe mixture was filtered
  2. customto give a solid, which
  3. washwas washed with water (15 ml)
  4. customDrying in vacuo

出典と根拠

ORDレコード
ord-bb3e168c11bd4080b841a93b67be50ad
出典データセット
uspto-grants-2004_12
特許番号
US06828441B2

反応ノート

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