Potassium Hydroxide → (3z)-2-[(Tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoic acid potassium salt

HRID 2306882ノート

反応式

HRID 2306882 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:10]([O:12]C)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+:21]>O>[K+:21].[C:1]([O:5][C:6]([NH:8][C:9]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:10]([O-:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 86585310Methyl (3Z)-2-[(tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoate

生成物 1

HCID 23689684(3z)-2-[(Tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoic acid potassium salt

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

The methyl (3Z)-2-[(tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoate product of Example 1d is taken up in DI water. To this is added KOH and the reaction mixture is stirred at 50° C. for 3 h. It is then concentrated under reduced pressure to give the desired title product.

後処理

  1. concentrationIt is then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a7c492f0292a424f947c1736dbaf5101
出典データセット
uspto-grants-2004_12
特許番号
US06828456B2

反応ノート

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