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HRID 23069作成日：2026年10月25日

p-Tolylacetic acid → N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester

https://huagongshe.com/reaction/23069

反応式

関与物質

役割名称HCID仕込み量
反応物p-Tolylacetic acidHCID 248474—
反応物2-Methylpropyl 2-aminopropanoate hydrochlorideHCID 86200109—
生成物N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl EsterHCID 22492098—

反応手順

Following General Procedure BB and using 4-methylphenylacetic acid (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06849650B2
出典データセットuspto-grants-2005_02
ORD IDord-5cd8391a6c5340d0b17c3743d90b092e
出典メモuspto-grants-2005_02