反応式
[CH3:1][C:2]1([CH3:14])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4](=[C:10]([CH3:13])[C:11]#[N:12])[CH2:3]1.[ClH:15].CC1(C)CC(C)(C)CC(=CCN)C1>>[ClH:15].[CH3:1][C:2]1([CH3:14])[CH2:7][C:6]([CH3:8])([CH3:9])[CH2:5][C:4](=[C:10]([CH3:13])[CH2:11][NH2:12])[CH2:3]1参加物
3
実験手順
Prepared from nitrile 21 according to the procedure for compound 22 (Example 10, b). Amine hydrochloride 23 obtained as a colorless solid. 1H-NMR: (CDCl3, TMS): 0.92 and 0.93 (total 12H, both s, c-Hex-3,5-CH3); 1.27 (2H, s, c-Hex-4-CH2); 1.89 (3H, s, propanamine-3-CH3); 1.99 and 2.01 (total 4H, both s, c-Hex-2,6-CH2); 3.64 (2H, br s, propanamine-1-CH2) and 8.40 ppm (3H, br s, NH3+).
出典と根拠
- ORDレコード
- ord-166d1cfd0dec474083085ff4f9086c5a
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06828462B2
関連ノート
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