Trifluoroacetic anhydride → 4H,5H,6H-7lambda5-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ylium-3-olate

HRID 2307250ノート

反応式

HRID 2307250 の反応式
[N+:1]([N:4]1[CH2:11][CH2:10][CH2:9][C@H:5]1[C:6]([OH:8])=[O:7])([O-])=O.FC(F)(F)C(OC(=O)C(F)(F)F)=O>CCOCC>[N:1]1[O:7][C:6]([O-:8])=[C:5]2[CH2:9][CH2:10][CH2:11][N+:4]=12

参加物

4

反応物 2

HCID 9845Trifluoroacetic anhydrideHCID 211172671-Nitro-L-proline

生成物 1

HCID 150890374H,5H,6H-7lambda5-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ylium-3-olate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

N-Nitroproline (17.0 g, 118 mmol) was suspended in ether (400 ml) and cooled in ice. Trifluoroacetic anhydride (16.5 ml, 120 mmol) was then added dropwise over 30 minutes and the mixture left to warm to room temperature whilst stirring over 16 hours. The mixture was evaporated in vacuo to an oil and purified by column chromatography on silica gel using an eluant of ethyl acetate to afford the title compound, 9.8 g.

後処理

  1. temperaturecooled in ice
  2. waitthe mixture left
  3. customThe mixture was evaporated in vacuo to an oil
  4. custompurified by column chromatography on silica gel using an eluant of ethyl acetate

出典と根拠

ORDレコード
ord-dd8f782405ce47f28831dfbf6f7f42ff
出典データセット
uspto-grants-2004_12
特許番号
US06831074B2

反応ノート

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