2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethanone oxime → 2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethylamine
反応式
[F:1][C:2]([F:19])([F:18])[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:7]=1)=[N:4]O>[OH-].[NH4+].CO.[Ni]>[F:19][C:2]([F:1])([F:18])[CH:3]([NH2:4])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:7]=1参加物
5
実験手順
A suspension of 2,2,2-trifluoro-1-(3-morpholin-4-yl-phenyl)-ethanone oxime (1.37 g) and Ra—Ni (1 mL) in a mixture of 3 ml of 30% ammonium hydroxide and 15 mL of MeOH was hydrogenated at 60 psi for 16 hours. The crude reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to give the title compound as an oil (1.3 g).
後処理
- customThe crude reaction mixture
- filtrationwas filtered through Celite
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-06c65228e5d74afb96402c67f1390346
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06831080B2
反応ノート
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