化工社化工社 化学情報印刷レポート · 研究参考用
Ammonium Chloride → 1-(4-Bromo-2-thienyl)-1-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| 反応物 | HCID 178418443 | HCID 178418443 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(4-Bromo-2-thienyl)-1-propanol | HCID 22606901 | — |
反応手順
10 g (52 mmol) of 4-bromothiophene-2-carbaldehyde are dissolved in 200 mL of ethyl ether and 20 mL of THF. 26.6 mL (78 mmol) of 3.0M ethylmagnesium bromide are added slowly. After 2 hours at room temperature, the reaction medium is poured into saturated ammonium chloride solution. After extraction, a yellow oil is obtained (m=11.5 g, Y=99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06831106B1 |
| 出典データセット | uspto-grants-2004_12 |
| ORD ID | ord-cc902a219f7946458d907dddb3b794c3 |
| 出典メモ | uspto-grants-2004_12 |