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Potassium Carbonate → 1-[4-(3-Hydroxyphenyl)-2-thiophenyl]-1-propanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromo-2-propionylthiophene | HCID 818932 | — |
| 反応物 | (3-(Methoxymethoxy)phenyl)boronic acid | HCID 22606941 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-[4-(3-Hydroxyphenyl)-2-thiophenyl]-1-propanone | HCID 22606920 | — |
反応手順
In a manner similar to that of Example 1(h), by reaction of 4.6 g (25 mmol) 3-methoxymethoxyphenylboronic acid (described in Example 1(g)) and 5 g (22.8 mmol) of 1-(4-bromo-2-thiophenyl)-1-propanone with 22.8 mL of 2.0M potassium carbonate and 1.32 g of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained in the form of a white solid (m.p.=112° C.; m=3.87 g: Y=73%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06831106B1 |
| 出典データセット | uspto-grants-2004_12 |
| ORD ID | ord-a3dfd4a2b2664d89af009c56b11c1896 |
| 出典メモ | uspto-grants-2004_12 |