2-(4-Fluorophenyl)benzaldehyde → N-[(4'-fluoro[1,1'-biphenyl]-2-yl)methyl]-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amine

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([CH:14]=O)=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[C@@H:16]1([NH2:26])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18][CH2:17]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][NH:26][C@@H:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][CH2:18][CH2:17]2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 13924752-(4-Fluorophenyl)benzaldehyde

HCID 70580741-Aminotetralin, (S)-

生成物 1

HCID 69722012N-[(4'-fluoro[1,1'-biphenyl]-2-yl)methyl]-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amine

実験手順

4′-Fluoro[1,1′-biphenyl]-2-carbaldehyde and (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine were processed as described in Example 1A to provide the title compound.

出典と根拠

ORDレコード: ord-b71db6ab2ba944e68c25a0f26d8f58cf
出典データセット: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06831193B2

反応ノート

読み込み中…