化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl 5-hydroxypyridine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chloro-5-hydroxypyridine | HCID 819821 | — |
| 反応物 | N,N-dimethylformamide ethanol | HCID 19794673 | — |
| 反応物 | HCID 178418416 | HCID 178418416 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 触媒 | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| 生成物 | Ethyl 5-hydroxypyridine-2-carboxylate | HCID 23145820 | — |
反応手順
Palladium acetate (267 mg), 1,1′-bis(diphenylphosphino)ferrocene (1.3 g) and triethylamine (3.2 mL) were added to an ethanol-DMF mixed solvent (1/1, 20 mL) of 6-chloropyridin-3-ol (1.5 g), and stirred overnight in a carbon monoxide atmosphere (1 atmospheric pressure) at 50° C. Ethanol was evaporated off under reduced pressure from the reaction solution, water was added to the resulting residue, and extracted with chloroform/methanol (10/1). The organic layer was dried with anhydrous magnesium sulfate, and the solvent was evaporated off under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=2/3) to obtain the entitled compound (500 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07566781B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-54ca4460d27647448c9b4774d48e1acd |
| 出典メモ | uspto-grants-2009_07 |