Hydrochloric Acid → 6-Bromo-3-hydroxyquinoline-4-carboxylic acid
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=[O:12].[OH-].[K+].BrC[C:17](=O)[C:18]([OH:20])=[O:19].Cl>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]=[CH:6][C:5]([OH:12])=[C:17]2[C:18]([OH:20])=[O:19]参加物
6
実験手順
A solution of 5-bromoisatin (2.26 g, 10 mmol) and potassium hydroxide (4.48 g, 80 mmol) in water (10 mL) was warmed until the materials were dissolved then cooled to room temperature, treated with bromopyruvic acid (2.3 g, 14 mmol), stirred for 6 days, adjusted to pH <7 with concentrated HCl, and filtered. The solid was washed with water and ethanol and dried to provide the desired product (1.5 g, 58%). MS (DCI/NH3) m/e 269 (M+H)+.
後処理
- dissolutionwere dissolved
- filtrationfiltered
- washThe solid was washed with water and ethanol
- customdried
出典と根拠
- ORDレコード
- ord-3f7e934123bc4bbd848614d0d557abb7
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06831175B2
反応ノート
読み込み中…