Phosphorus oxychloride → 4,7-Dichloropyrido[2,3-d]pyrimidine

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:10](O)=[N:9][CH:8]=[N:7][C:6]=2[N:12]=1.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:10]1[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[N:12][C:6]=2[N:7]=[CH:8][N:9]=1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 178518043HCID 178518043、化合物

生成物 1

HCID 226077594,7-Dichloropyrido[2,3-d]pyrimidine収率 73%

実験手順

A mixture of Example 140C (1 g, 5.5 mmol) in phosphorus oxychloride (40 mL) was refluxed for 2 h then cooled and evaporated. The residue was taken into ethyl acetate (75 ml), washed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml). The ethyl acetate was evaporated to yield 0.8 g of product (73%).

後処理

temperaturethen cooled
customevaporated
washwashed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml)
customThe ethyl acetate was evaporated

出典と根拠

ORDレコード: ord-2b7a77ded1d942b688d3a870805edb11
出典データセット: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06831175B2

反応ノート

読み込み中…

参加物