Acetamidine → 7-Bromo-2-methylquinazoline
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4](F)[CH:3]=1.[C:11]([NH2:14])(=[NH:13])[CH3:12]>CC(N(C)C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([CH:6]=[N:13][C:11]([CH3:12])=[N:14]2)=[CH:8][CH:9]=1参加物
4
反応条件
- 温度
- 140 °C
実験手順
The 4-Bromo-2-fluoro-benzaldehyde (1 g, 4.9 mmol), acetamidine and DMA were mixed and heated to 140° C. for 5 hours. The mixture was cooled to room temperature and dried under vacuum. The mixture was purified by flash column afforded 47 mg product in 4% yield. MS (ESI) m/e 223 (M+1)+.
後処理
- temperatureThe mixture was cooled to room temperature
- customdried under vacuum
- customThe mixture was purified by flash column
出典と根拠
- ORDレコード
- ord-0e53fc394a054dc2b1c292595095782c
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06831175B2
反応ノート
読み込み中…