Methyl 2-chloronicotinate → HCID 22603050、化合物

HRID 2307870ノート

反応式

HRID 2307870 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.Cl[C:14]1[C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=1>COCCO.O>[CH3:11][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:14]2[C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:7][CH:6]=1)=[O:12]

参加物

5

反応物 2

HCID 819931Methyl 2-chloronicotinateHCID 51510441-(4-Aminophenyl)-2-methylpropan-1-one

生成物 1

HCID 22603050HCID 22603050、化合物収率 118.9%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 80192-Methoxyethanol溶媒

実験手順

A mixture of 1-(4-aminophenyl)-2-methyl-1-propanone (0.0637 mol) and methyl 2-chloro-3-pyridinecarboxylate (0.0637 mol) in 2-methoxyethanol (200 ml) was stirred and refluxed for 90 hours. The mixture was taken up in water and EtOAc and extracted with EtOAc. The organic layer was separated, dried, filtered and the solvent was evaporated, yielding 22.6 g of methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate (interm. 20).

後処理

  1. temperaturerefluxed for 90 hours
  2. extractionEtOAc and extracted with EtOAc
  3. customThe organic layer was separated
  4. customdried
  5. filtrationfiltered
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-59e77216d5154160814d170bd91cbc93
出典データセット
uspto-grants-2004_12
特許番号
US06833375B2

反応ノート

読み込み中…