benzyl (2S,4R)-2-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate → ((2S,4R)-4-methoxypyrrolidin-2-yl)methanol
反応式
C(OC([N:11]1[CH2:15][C@H:14]([O:16][CH3:17])[CH2:13][C@H:12]1[CH2:18][OH:19])=O)C1C=CC=CC=1>CO>[CH3:17][O:16][C@H:14]1[CH2:15][NH:11][C@H:12]([CH2:18][OH:19])[CH2:13]1参加物
3
実験手順
To 1.00 g (5.62 mmol) of (2S,4R)-2-Hydroxymethyl-4-methoxy-pyrrolidine-1-carboxylic acid benzyl ester in 3 mL of MeOH was added 0.1 g of 10% Pd(C) under 1 atmosphere of H2 while stirring for 12 h. The mixture was filtered through 0.22 μM Teflon filter concentrated and put under high vacuum for 2 h to give 0.44 g (96%) of ((2S,4R)-4-Methoxy-pyrrolidin-2-yl)-methanol as clear oil. LCMS (APCI) (M+H+) m/z: 266.2.
後処理
- filtrationThe mixture was filtered through 0.22 μM Teflon
- filtrationfilter
- concentrationconcentrated
- waitput under high vacuum for 2 h
出典と根拠
- ORDレコード
- ord-cc5ce8e680d24746ba69825aabfbc9c3
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06833456B2
反応ノート
読み込み中…