Potassium Hydroxide → 3-(4-Butoxy-3-methoxyphenyl)prop-2-enoic acid

HRID 2308116ノート

反応式

HRID 2308116 の反応式
[OH-].[K+].C[O:4][C:5](=[O:21])/[CH:6]=[CH:7]/[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH3:18])=[C:10]([O:19][CH3:20])[CH:9]=1>CO.O>[CH2:15]([O:14][C:11]1[CH:12]=[CH:13][C:8](/[CH:7]=[CH:6]/[C:5]([OH:21])=[O:4])=[CH:9][C:10]=1[O:19][CH3:20])[CH2:16][CH2:17][CH3:18]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 20744699(E)-4-butoxy-3-methoxycinnamic acid methyl ester

生成物 1

HCID 59335643-(4-Butoxy-3-methoxyphenyl)prop-2-enoic acid収率 92.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

10 g (0.15 mmol) potassium hydroxide were dissolved in a mixture of 200 ml methyl alcohol and 5 ml water. 4.85 g (18.35 mmol) (E)-4-butoxy-3-methoxycinnamic acid methyl ester was added. The reaction mixture was subsequently heated to 60° C. After 2.5 h the mixture was concentrated by evaporation. The residue was dissolved in 100 ml cold water and acidified to pH=1 with 13.5 ml hydrochloric acid 37 wt. %. The product was filtered off, washed with water and dried at 50° C. under vacuum to give 4.24 g (92%) (E)-4-butoxy-3-methoxycinnamic acid as white crystals.

後処理

  1. concentrationAfter 2.5 h the mixture was concentrated by evaporation
  2. dissolutionThe residue was dissolved in 100 ml cold water
  3. filtrationThe product was filtered off
  4. washwashed with water
  5. customdried at 50° C. under vacuum

出典と根拠

ORDレコード
ord-b522faf5ca3649699744efc2835c2bb8
出典データセット
uspto-grants-2004_12
特許番号
US06833421B1

反応ノート

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