Hydrochloric Acid → HCID 12134606、化合物

HRID 2308193

反応式

HRID 2308193 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23].Cl>CC(O)CCC(O)C>[F:19][C:20]1[CH:21]=[C:22]([NH:23][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:24]=[CH:25][CH:26]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 97423-FluoroanilineHCID 11161454HCID 11161454、化合物2 回

生成物 1

HCID 12134606HCID 12134606、化合物

試薬・触媒・溶媒 1

HCID 180492,5-Hexanediol溶媒

実験手順

The titled compound of Example 7, 4-chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline (40 mg, 0.15 mmol) was dissolved in diisopropanol (2.5 ml), where was then added 3-fluoroaniline (33 mg, 0.3 mol) and concentrated hydrochloric acid of catalytic amount, followed by refluxing for 24 hours. Then, the reaction mixture was cooled down to a room temperature to obtain a solid, which was then filtered, washed with diisopropanol and dried under vacuum to prepare the titled compound (24 mg, 47%, m.p. 257-260° C.; mass (m/z;rel) 340.10).

後処理

  1. temperatureby refluxing for 24 hours
  2. customto obtain a solid, which
  3. filtrationwas then filtered
  4. washwashed with diisopropanol
  5. customdried under vacuum
  6. customto prepare the titled compound (24 mg, 47%, m.p. 257-260° C.; mass (m/z;rel) 340.10)

出典と根拠

ORDレコード
ord-71add139fb124842afbc23f1105c6e5c
出典データセット
uspto-grants-2004_12
特許番号
US06835735B2

関連ノート

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