Hydrochloric Acid → HCID 10165721、化合物

HRID 2308305

反応式

HRID 2308305 の反応式
[N:1]1[C:10]2[CH:9]([N:11]([CH2:30][C:31]3[CH:47]=[CH:46][C:34]([CH2:35][NH:36][S:37]([C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=4)(=[O:39])=[O:38])=[CH:33][CH:32]=3)[CH2:12][C:13]3[N:17](COCC[Si](C)(C)C)[C:16]4[CH:26]=[CH:27][CH:28]=[CH:29][C:15]=4[N:14]=3)[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl>>[NH:14]1[C:15]2[CH:29]=[CH:28][CH:27]=[CH:26][C:16]=2[N:17]=[C:13]1[CH2:12][N:11]([CH2:30][C:31]1[CH:32]=[CH:33][C:34]([CH2:35][NH:36][S:37]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=2)(=[O:38])=[O:39])=[CH:46][CH:47]=1)[CH:9]1[C:10]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH2:6][CH2:7][CH2:8]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 68896453pyridine-2-sulfonic acid 4-({(5,6,7,8-tetrahydro-quinolin-8-yl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-ylmethyl]-amino}-methyl)-benzylamide

生成物 1

HCID 10165721HCID 10165721、化合物収率 85%

実験手順

Using General Procedure E: Reaction of pyridine-2-sulfonic acid 4-({(5,6,7,8-tetrahydro-quinolin-8-yl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1 H-benzoimidazol-2-ylmethyl]-amino}-methyl)-benzylamide (100 mg, 0.15 mmol), and 6N HCl (3.9 mL) for 3 h at 50° C. followed by column chromatography on silica gel (CH2Cl2/MeOH/NH4OH: 94:3:3) gave the title compound (68 mg, 85%) as a white foam.

出典と根拠

ORDレコード
ord-74a6d1980b2b4bf6bd942b0e7529eb67
出典データセット
uspto-grants-2004_12
特許番号
US06835731B2

関連ノート

読み込み中…