Diphenyl Ether → Ethyl 6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylate
反応式
C1(OC2C=CC=CC=2)C=CC=CC=1.[I:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][CH:22]=[C:23]([C:29]([O:31]CC)=O)[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:17][CH:16]=1>CC(CCC)C>[I:14][C:15]1[CH:16]=[C:17]2[C:18](=[CH:19][CH:20]=1)[NH:21][CH:22]=[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:29]2=[O:31]参加物
4
実験手順
Diphenyl ether (175 ml) was heated to reflux temperature, and Intermediate 10 was gradually added down an air condenser. Once all the reagent had been added the mixture was heated under reflux for a further 30 min. The mixture was then cooled and 2-methylpentane (200 ml) was added. The solid formed was collected by filtration to give the title compound (24.6 g).
後処理
- additionwas gradually added down an air condenser
- additionOnce all the reagent had been added the mixture
- temperaturewas heated
- temperatureunder reflux for a further 30 min
- temperatureThe mixture was then cooled
- customThe solid formed
- filtrationwas collected by filtration
出典と根拠
- ORDレコード
- ord-54a385256a874b199dd6d9b03ea3d8d9
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07566786B2
反応ノート
読み込み中…