4-Methoxy-alpha-toluenethiol → 4-{[3-(Methyloxy)phenyl]amino}-6-({[4-(methyloxy)phenyl]methyl}thio)-3-quinolinecarboxamide

HRID 230861ノート

反応式

HRID 230861 の反応式
Cl.I[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([NH2:15])=[O:14])=[C:6]2[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=1.CC(C)([O-])C.[K+].[CH3:31][O:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][SH:40])=[CH:35][CH:34]=1.O(C1C=CC=CC=1P(C1C=CC=CC=1)C1C=CC=CC=1)C1C=CC=CC=1P(C1C=CC=CC=1)C1C=CC=CC=1>CN(C)C=O>[CH3:24][O:23][C:19]1[CH:18]=[C:17]([NH:16][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([S:40][CH2:39][C:36]4[CH:37]=[CH:38][C:33]([O:32][CH3:31])=[CH:34][CH:35]=4)[CH:4]=3)[N:9]=[CH:8][C:7]=2[C:13]([NH2:15])=[O:14])[CH:22]=[CH:21][CH:20]=1

参加物

6

反応物 4

HCID 804074-Methoxy-alpha-toluenethiolHCID 4285986Bis[2-(diphenylphosphino)phenyl] etherHCID 23665647Potassium tert-butoxideHCID 674246056-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

生成物 1

HCID 577632404-{[3-(Methyloxy)phenyl]amino}-6-({[4-(methyloxy)phenyl]methyl}thio)-3-quinolinecarboxamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

Intermediate 14 (0.020 g), potassium tert-butoxide (0.0061 g) and [4-(methyloxy) phenyl]methanethiol (available from Aldrich) (0.007 ml) were added to a stirred solution of tris(dibenzylidineacetone)dipalladium(0) (0.002 g) and (oxydi-2,1-phenylene)bis (diphenylphosphine) (0.002 g) in N,N-dimethylformamide (1.5 ml), and the mixture was heated under microwave irradiation at 60° C. for 8 min. The solvent was evaporated in vacuo, and the residue purified by Mass Directed Preparative HPLC (Method A) to give the title compound (0.0048 g).

後処理

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by Mass Directed Preparative HPLC (Method A)

出典と根拠

ORDレコード
ord-28ee6ea5069f418aae92f3f69428b049
出典データセット
uspto-grants-2009_07
特許番号
US07566786B2

反応ノート

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