Water → 6'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

HRID 230893

反応式

HRID 230893 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21].O>CC(C)=O>[OH:1][C:2]1[C:3]([C:9](=[O:11])[CH3:10])=[C:4]([O:8][CH2:19][C:20]([O:22][CH3:23])=[O:21])[CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 696872',6'-Dihydroxyacetophenone

生成物 1

HCID 105370846'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a mixture of 2′,6′-dihydroxyacetophenone (6 g) and potassium carbonate (5.72 g) in acetone (20 mL) was added methyl bromoacetate (3.73 mL), and the mixture was stirred at room temperature for 5 days. To the reaction mixture was added water, and the precipitated crystals were collected by filtration. The crystals were washed with water and dried under reduced pressure to give the title compound (7.89 g).

後処理

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-9697439f8c5f4eaf8fdafdd370708a5d
出典データセット
uspto-grants-2009_07
特許番号
US07566699B2

関連ノート

読み込み中…