1-(2-Hydroxyethyl)piperazine → 2-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol

HRID 2309032

反応式

HRID 2309032 の反応式
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>C(O)C>[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][N:17]([CH2:7][C:6]2[CH:9]=[CH:10][C:3]([S:2][CH3:1])=[CH:4][CH:5]=2)[CH2:16][CH2:15]1

参加物

5

反応物 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 8471TriethylamineHCID 701281-(Chloromethyl)-4-(methylthio)benzene

生成物 1

HCID 20575972-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol収率 71.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-(methylthio)benzyl chloride (28.6 g), 1-(2-hydroxyethyl)piperazine (21.6 g), triethylamine (16.8 g), and ethanol (250 ml) is stirred at room temperature for 5 hours. The ethanol is then removed in vacuo and water added to the residue. The product is extracted with ether, dried, and the ether evaporated to give 31.6 g of 1-(2-hydroxyethyl)-4-[4-(methylthio)benzyl] piperazine as an orange oil, suitable for use in the next reaction.

後処理

  1. customThe ethanol is then removed in vacuo and water
  2. additionadded to the residue
  3. extractionThe product is extracted with ether
  4. customdried
  5. customthe ether evaporated

出典と根拠

ORDレコード
ord-5e33a732aad4425ba516fd9cf0aaad75
出典データセット
uspto-grants-1987_09
特許番号
US04692448

関連ノート

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