Potassium Hydroxide → N-(3-methyl-4-hydroxy-5-tert-butylphenylthiomethyl)phthalimide

反応式

[CH3:1][C:2]1[CH:3]=[C:4]([SH:13])[CH:5]=[C:6]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:7]=1[OH:8].[OH-].[K+].Cl[CH2:17][N:18]1[C:22](=[O:23])[C:21]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:20]2[C:19]1=[O:28]>>[CH3:1][C:2]1[CH:3]=[C:4]([S:13][CH2:17][N:18]2[C:19](=[O:28])[C:20]3=[CH:27][CH:26]=[CH:25][CH:24]=[C:21]3[C:22]2=[O:23])[CH:5]=[C:6]([C:9]([CH3:10])([CH3:12])[CH3:11])[C:7]=1[OH:8]

参加物

反応物 3

HCID 14797Potassium Hydroxide

HCID 87154Chloromethylphthalimide

HCID 13547656HCID 13547656、化合物

生成物 1

HCID 14047795N-(3-methyl-4-hydroxy-5-tert-butylphenylthiomethyl)phthalimide収率 46.3%

実験手順

The procedure of Example 1 was repeated using 8.46 grams of 3-methyl-4-hydroxy-5-tert-butylbenzenethiol, 1.72 grams of potassium hydroxide, and 8.43 grams of N-(chloromethyl) phthalimide . Recrystallization from ethyl acetate-heptane afforded 7.1 grams of product with m.p. 114°-116° C.

後処理

customRecrystallization from ethyl acetate-heptane

出典と根拠

ORDレコード: ord-8c7bb637d4454861b3442f92a91bf510
出典データセット: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04692532

反応ノート

読み込み中…